Monitoring of infliximab trough levels and anti-infliximab antibodies in inflammatory bowel diseases: A comparison of three commercially available ELISA kits.

There are many studies presenting biological data and some commercially available ELISA kit for monitoring the serum infliximab through rate (s-IFXt) and anti-drug antibodies (adab). We propose to compare the technical characteristics and the results of three different tests in a cohort of 35 patients under infliximab (IFX) and suffering from inflammatory bowel disease (IBD) .

S-IFXt and manners are systematically measured by the three ELISA kits: Lisa-Tracker Duo infliximab (Theradiag®), Ridascreen® IFX Monitoring (R-Biopharm AG®) and Promonitor® IFX (Progenika Biopharma SA®) .the main technical features that differ between the kit for measuring s-IFXt are: (i) TNF coating, (ii ) revelation complex immune strategy and / or (iii) interference with anti-TNF agents other.

For measuring kit courtesy, they step revelation and unit results. There is a very good mathematical correlation of s-IFXt between tests But Bland-Altman analysis denoted by (i) s-IFXt were on average 48-69% higher in Ridascreen® than two other tests, and (ii) an increase in s- IFXt higher with Promonitor® compared to Lisa-Tracker. As a result, there are some major differences between test for classification of s-IFXt into concentration range.

Although the unit unstandardized, qualitatively Pairwise Comparisons show a perfect agreement between the three pairs of data courtesy assays.Our show that the test is evaluated quantitatively not interchangeable due to substantial variation in some of the results may lead, for some patients, for divergent therapeutic decisions.

We are reminded to be careful when comparing results of the study were excluded from different kits and suggested using the same assay for longitudinal follow-up of patients with IBD.

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